If you follow what we do at GnuPharma you know that we are deep into ways to modulate the endocannabinoid system with non-cannabis plants. We started discussing these concepts about 4 years ago now and are probably the first to coin the term “master regulatory system”. We are always learning new things and we usually at least hint at these new things in articles and blogs.
Several years ago, it looked like cannabis and a small set of a few other plants were about the only way to modulate the endocannabinoid system for health effects. Cannabis appears to have all the necessary “knobs and levers” to provide our bodies with the resources to properly regulate. But if just cannabis and a few plants can provide these NECESSARY resources to our endocannabinoid system, how have we survived as a species? In fact how has everything on earth, expect insects, survived? If the NECESSARY resources to run our master regulatory are only available from a few plants, then we would only live in the places those plants grew. Simple survival and simple logic. In fact all life but insects would also be living ONLY in the regions where these plants grew natively.
We know that life is abundant and has developed everywhere on the plant. Non-insect life can be found in every nook and cranny on this planet. What this indicates is that the natural resources we need to “regulate our vehicles” would have to be found, in abundance, throughout nature. If this was not the case, then life would be isolated to the regions where those resources were readily available.
It is now looking like the “why” of a plants ability to effect humans (or other non insect animals) is because of the action of the molecules in the plant to cause actions and changes within the endocannabinoid system or a sub system which is regulated by the endocannabinoid system. For instance beta-caryophollene is found in many many herbs and spices and is an effector of the endocannabinoid system. Curcumin from turmeric is medicinal due to its action in the endocannabinoid system.
The study below and quote from the summary of the study are mindblowing when you consider their ramifications… “Taking altogether the multiple pharmacological properties, anthocyanins appear as polypharmacological agent for diseases involving dysregulation of ECS (endocannabinoid system) and PPARs”. Translation=Anthocyanins (from blueberries or any colored fruit) have the necessary molecules to modulate both the CB1 neuro, the CB2 neuro, and can block both neuro’s allowing ALL of the necessary resources to fully modulate the endocannabinoid system and thereby “regulate” the “disregulation”.
Basically colored fruits can contain all of the necessary natural resources to run your endocannabinoid system. What we have found at GnuPharma, is that when these natural resources are presented, your bodies does what it should and uses these resources to re-regulate the dis-regulations. We are just beginning to understand this fascinating and almost magical phenomenon and are realizing that we can also “target” certain areas of the body by using herbs that also target these areas with proper resources. We really work very logically and simply at the macro.
“Let food be thy medicine and medicine be thy food”…old Hippocrates sure knew a thing or two…wonder if he knew about the endocannabinoid system?
Anthocyanins are water-soluble polyphenol compounds abundantly found in colored fruits and vegetables particularly in red and blue fruits such as blueberry, cranberry, and red cabbage. These have been shown to regulate several intracellular functions. Numerous studies have shown that anthocyanins and anthocyanidins exhibit antioxidant, redox-inflammatory signaling which contributes to its analgesic, cardioprotective, neuroprotective, anticancer, atherogenic, antihyperlipidemic, and antihypertensive effects. The cannabinoid receptor activity has been demonstrated by competitive radioligand assays of cyanidin (K i = 16.2 μM) and delphinidin (K i = 21.3 μM) for hCB1 receptors whereas similar affinities for CB2 receptors have been shown by cyanidin (K i = 33.5 μM), delphinidin (K i = 34.3 μM), and peonidin (K i = 46.4 μM) . However, the cyanidin derivatives such as cyanidin-3,5-di-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-galactoside, cyanidin-3-O-rutinoside, malvidin, and pelargonidin showed inhibition of both CB1 and CB2 receptors. Additionally, cyanidin-3-O-β-glucoside also reported to activate all forms of PPARs and reduces hepatic lipids by altering the expression of genes involved in lipid metabolic pathways. Taking altogether the multiple pharmacological properties, anthocyanins appear as polypharmacological agent for diseases involving dysregulation of ECS and PPARs .